Inventaire - je vrienden en communities zijn je beste bibliotheek - Inventaire

Deep generative models of genetic variation capture the effects of mutations

auteur

Debora Marks

gepubliceerd in: Nature Methods

publicatiedatum: 2018-09-24

Cites articles 73

Date

Titel

Auteurs

2019-03-12

Learning protein constitutive motifs from sequence data

Jérôme Tubiana, Simona Cocco, Rémi Monasson
2018-10

Accurate classification of BRCA1 variants with saturation genome editing

Jay Shendure
2018-05-21

Multiplex assessment of protein variant abundance by massively parallel sequencing

Kenneth A Matreyek, Beth Martin, Melissa A Chiasson, Vanessa E. Gray, Martin Kircher, Ronald J Hause, William E Evans, Douglas M Fowler, Jay Shendure
2018-03-28

Mapping mutational effects along the evolutionary landscape of HIV envelope.

Jesse D Bloom, Sarah K Hilton, Adam S Dingens, Julie Overbaugh, Hugh K Haddox
2018-01-12

Automatic Chemical Design Using a Data-Driven Continuous Representation of Molecules

Rafael Gómez-Bombarelli, Jennifer N Wei, Dennis Sheberla, Alán Aspuru-Guzik, Jorge Aguilera-Iparraguirre, Timothy D. Hirzel, David Duvenaud
2018-04-05

Accurate functional classification of thousands ofBRCA1variants with saturation genome editing

Molly Gasperini, Gregory M. Findlay, Jay Shendure
2017-11-09

Three-body interactions improve contact prediction within direct-coupling analysis.
2017-12-21

A framework for exhaustively mapping functional missense variants

Frederick P Roth, Jochen Weile, Carles Pons, Natascha H M van Lieshout, Marc Vidal, David E Hill, Marta Verby, Murat Tasan, Guihong Tan, Patrick Aloy, Atina G Cote, Joseph Mellor, Cassandra Wong
2017-11-10

Negative Epistasis in Experimental RNA Fitness Landscapes

Devin P Bendixsen, Eric J Hayden
2017-09-01

Variant Interpretation: Functional Assays to the Rescue.

Jay Shendure
2017-07-07

Deconstruction of the Ras switching cycle through saturation mutagenesis

John Kuriyan, Tanja Kortemme, Pradeep Bandaru, Christine L Gee, Neel H Shah, John P Barton, Joshua C Cofsky, Moitrayee Bhattacharyya, Yasushi Kondo, Arup Chakraborty
2017-06-06

Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded

Emily E Wrenbeck, Laura R Azouz
2017-03-15

Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence

Claus O Wilke
2017-03-13

Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data

Yi-Fei Huang, Brad Gulko
2017-03-06

Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

Yvonne H Chan, Sergey V Venev
2017-01-16

Mutation effects predicted from sequence co-variation

Chris Sander (scientist), Debora Marks, Thomas A Hopf, Michael Springer
2016-12-01

RNA Structural Determinants of Optimal Codons Revealed by MAGE-Seq

Eric D Kelsic, Hattie Chung, Roy Kishony
2016-10-01

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

Gad Getz, Levi A Garraway, Tarjei S Mikkelsen, David E Root, Federica Piccioni, Alex B. Burgin
2016-09-01

Structured States of Disordered Proteins from Genomic Sequences

Chris Sander (scientist), Bonnie Berger, Debora Marks, Thomas A Hopf, Agnes Toth-Petroczy
2016-09-01

The power of multiplexed functional analysis of genetic variants

Jay Shendure
2016-06-03

Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin

Jesse D Bloom
2016-05-10

The complete local genotype-phenotype landscape for the alternative splicing of a human exon

Juan Valcárcel
2016-04-25

Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting

Tanja Kortemme, David Mavor, Kyle A Barlow, Samuel Thompson, Benjamin A Barad, Seth D Axen, Elena Cáceres, Lukas Kenner, Bruk Mensa, Leanna S Morinishi, James S Fraser
2016-04-13

3D RNA and Functional Interactions from Evolutionary Couplings

Chris Sander (scientist), Debora Marks, Caleb Weinreb
2016-04-14

The fitness landscape of a tRNA gene

Wenfeng Qian
2016-04-19

Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
2016-03-24

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
2016-02-29

Biophysical principles predict fitness landscapes of drug resistance

João V Rodrigues, Shimon Bershtein, Dan Hartl
2015-10-17

Evolving new protein-protein interaction specificity through promiscuous intermediates

Julien Herrou, Sean Crosson, Laub MT
2015-10-06

Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.

Martin Weigt, Olivier Tenaillon
2015-09-22

Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli

Justin R Klesmith, John-Paul Bacik, Ryszard Michalczyk
2015-09-03

Large-scale determination of previously unsolved protein structures using evolutionary information

Sergey Ovchinnikov, David Baker, Nick V. Grishin, Hetunandan Kamisetty, Hahnbeom Park

Artike - wd:Q91703100

Welcome to Inventaire

de bibliotheek van je vrienden en communities

you are offline